I'm running 245/75R16 on 16x7s not sure what the off set is. no issues yet. though i'm on a 2" lift. it sets your speedo off by +4 at 100Kmh (speedo says 100 but your actually doing 104-106) got them engineered but was told i didn't have to.
Put some 265/75R16 on 16x8s 0 off set, had some scrubbing on the mad flaps and sway bar on full lock. JAX fixed the full lock issue but i didn't look into the mad flap issue. got rid of them real quick.
hope this helps. i'm also looking into putting 265/75R16 back on just not sure what offset you need.