yep i'm running from the headphone out on my carputer, and splitting it into 2 RCA channels - front and sub... to be honest, i think the sound is pretty decent, even though im running everything off a single unpowered headphone output... as long as you set your amp up right, you shouldnt have a problem. of course its not going to compare with a 24bit DAC signal coming out of some fancy head unit, but i'm totally satisfied with what i get. ultimately, i would buy an external USB sound card (i've been looking at the audigy NX or something), but im happy enough with what i have that i can't justify it.